Thus, small amounts of Vitamin C are released over a prolonged period of time from the matrix.Ĭholecalciferol (Vitamin D3) is a BCS – II vitamin with challenges to aqueous solubility which results in low dissolution and limits absorption. The Citrazinc SR tablets manufactured with this Matrix technology provide effective & desired outcomes in a controlled manner. The gel layer controls both the diffusion of water into the system and the diffusion of drug out of the system up to a desired period of time with a predetermined rate of release. When the matrix tablet is exposed to GI fluids, the surface of the tablet is wetted and the polymer hydrates to form a gel-like structure around the matrix. The mechanism of drug release from the matrix is based on the dissolution of the drug and its diffusion through the hydrated portion of the matrix.
The active material is entrapped inside the matrix and is released slowly from the matrix. Citrazinc SR tablet was developed using matrix technology in which the drug, polymer and additional excipients are uniformly blended, granulated and then compressed into tablets.
The Matrix technology used in Citrazinc SR facilitates release of small amounts of active ingredients, from the tablet in a controlled manner, over an extended period of time.